LDS-L1 Experimental Ultrafiltration System Introduction: Tangential flow filtration is currently a widely used membrane separation method. The sample is driven by pressure, and the contents are separated by membrane filtration according to different molecular sizes, achieving the goals of removing pyrogen, displacing solution environment, purification, and concentration. The membrane components for tangential flow filtration are usually membrane packs or hollow fiber columns, both of which have multiple models to meet different usage needs. The type and pore size of the membrane material, solution circulation flow rate, pressure on both sides of the membrane, sample temperature, process time, and other parameters are very important for tangential flow filtration. They determine the final process effect, as well as the feasibility and specific plan for large-scale production. The tangential flow filtration equipment at the laboratory scale is dedicated to obtaining feasible process solutions and reliable process parameters, determining suitable process parameters for large-scale experiments and production, and providing effective basis for equipment or system selection. This system is mainly applied in the fields of sample concentration, purification, dialysis, replacement buffer, and solution heat removal. During the process, the weight of the sample, pre membrane pressure, reflux pressure, permeation pressure, transmembrane pressure TMP, and other data can be displayed and recorded through a paperless recorder or LCD panel. Application areas: 1. Purification of chemical drug liposomes, such as doxorubicin hydrochloride liposomes, irinotecan liposomes, etc; 2. Purification of nucleic acid drugs and vaccines, such as lipid nanoparticles, polymer nanoparticles, mRNA LNP, siRNA LNP, etc; 3. Separation and purification of biological cell products, which can collect cells from fermentation broth and remove cell debris, etc; 4. Purification of vaccines, monoclonal antibodies, and recombinant protein drugs; 5. Replace the buffer solution; 6. Other applications for separation and purification based on the principle of molecular size. Technical parameter: Model: LDS-L1&LDS-L2 Minimum sample volume: 30 mL Pressure range: -1-5 bar Flow rate range: 1-2200 mL/min Weight range: 0-4100 g Display data: Pf (feed pressure), Pr (reflux pressure), Pp (permeate pressure), TMP (transmembrane pressure), △ P (pressure drop), etc Operation mode: Manual (LDS-L1) Automatic (LDS-L2) Applicable containers: glass containers, stainless steel containers, etc Applicable membrane materials: PES/cellulose membrane package, hollow fiber column Membrane package specification: 5-1000 kD; 0.01 – 0.1 m2
Introduction: Tangential flow filtration is currently a widely used membrane separation method. The sample is driven by pressure, and the contents are separated by membrane filtration according to different molecular sizes, achieving the goals of removing pyrogen, displacing solution environment, purification, and concentration. The membrane components for tangential flow filtration are usually membrane packs or hollow fiber columns, both of which have multiple models to meet different usage needs. The type and pore size of the membrane material, solution circulation flow rate, pressure on both sides of the membrane, sample temperature, process time, and other parameters are very important for tangential flow filtration. They determine the final process effect, as well as the feasibility and specific plan for large-scale production. The tangential flow filtration equipment at the laboratory scale is dedicated to obtaining feasible process solutions and reliable process parameters, determining suitable process parameters for large-scale experiments and production, and providing effective basis for equipment or system selection. This system is mainly applied in the fields of sample concentration, purification, dialysis, replacement buffer, and solution heat removal. During the process, the weight of the sample, pre membrane pressure, reflux pressure, permeation pressure, transmembrane pressure TMP, and other data can be displayed and recorded through a paperless recorder or LCD panel.
