Introduction: DB-LB100 hot and cold plate pain tester is an instrument developed for the screening of acute pain and analgesic drugs, appendix reflex test or animal foot tenderness irradiation test, but these are the normal stimulation response threshold of animals, belonging to one Physiological pain. Physiological pain and pathological pain are essentially different. Physiological pain is a kind of alarm system for self-protection for survival, and pathological pain is a disease that hinders survival. Because the performance and mechanism of the two kinds of pain are different, the research methods for analgesic drugs are also different. For example, some analgesic drugs have better analgesic effects on physiological and pathological pain. However, some drugs only have an effect on physiological pain, so different experimental methods can be used to screen out drugs with different points of action. The DB-LB100 hot and cold plate pain tester is an instrument that can perform physiological pain test and pathological pain test on the same instrument.
When the surface temperature of the DB-LB100 hot and cold plate pain tester is set to 4 °C, the test drug can significantly change the time and number of lifts on the cold plate for the animal that causes the pathological pain model of the sciatic nerve. When the plate surface temperature is set to 55 ° C, the physiological pain threshold of the animal can be accurately measured to determine the type and effect of the analgesic of the test drug. The advantage of this experimental method is that the animal is tested in an unconstrained state, avoiding human interference and harm to the animal, and is subject to the experimenter's because of its simple and convenient operation, clear indicators, and more accurate reflection of the pain behavior of the animal. favorite. In addition to the set temperature (-2 ° C ~ 65 ° C), high temperature control accuracy (± 0.25 ° C), the timing error is small (error 0.01 seconds), and the LCD display Chinese display, comes with a miniature The printer, USB computer interface and animal storage are fast, the data display is complete, the animal is convenient to watch, and the advantages of the full lifting time and the number of lifting times are automatically accumulated. It is a true dual-use analgesic drug experimental instrument.
Introduction: DB-LB100 hot and cold plate pain tester is an instrument developed for the screening of acute pain and analgesic drugs, appendix reflex test or animal foot tenderness irradiation test, but these are the normal stimulation response threshold of animals, belonging to one Physiological pain. Physiological pain and pathological pain are essentially different. Physiological pain is a kind of alarm system for self-protection for survival, and pathological pain is a disease that hinders survival. Because the performance and mechanism of the two kinds of pain are different, the research methods for analgesic drugs are also different. For example, some analgesic drugs have better analgesic effects on physiological and pathological pain. However, some drugs only have an effect on physiological pain, so different experimental methods can be used to screen out drugs with different points of action. The DB-LB100 hot and cold plate pain tester is an instrument that can perform physiological pain test and pathological pain test on the same instrument.
