TD-12AT automatic transdermal diffusion system Introduction: The TD-12AT automatic transdermal diffusion system consists of a diffusion host and a sample collector. The TD-12 transdermal diffusion host consists of two sets of 6+1 diffusion cells, with 6 diffusion cells used for diffusion experiments and the 7th diffusion cell used to monitor the temperature of the receiving solution. It meets the requirements of the US Pharmacopoeia and is a reliable and reproducible method for semi solid dosage form release determination. Mainly used for drug transdermal release tests of ointments, ointments, coatings, films, aerosols, and other formulations, to study the efficiency of drug penetration through the skin through a model of skin absorption. Features: 1. The diffusion system adopts a dry heating method with high heating efficiency, and the temperature of the receiving and donor rooms is accurately controlled (≤ 0.2 ℃); 2. The dual insulation design of anti evaporation cap and protective cover prevents solvent evaporation in the formulation and prevents the temperature of the pool and drug from being affected by the external environment; 3. Real time monitoring and recording of the temperature of the dry heating block and the receiving pool medium (independent temperature monitoring pool), and generating temperature curves; 4. Same temperature rehydration design to avoid the impact of rehydration temperature fluctuations on release or transdermal penetration; 5. Improved Franz vertical diffusion cell, made of glass material, with good heat transfer and fixed area of 1.77cm2（ φ= 15mm) release area; 6. Quantitative administration: Different thicknesses of quantitative loops allow for flexible control of different dosage levels; 7. Variable volume of diffusion pool: With different volumes of stirrers, the volume of diffusion pool can be flexibly changed; 8. Adaptive compression device: Spring+knob design, adaptive clamping and adjustment of the gap between the receiving room and the donor room. 9. Automatic exhaust design ensures complete contact between the skin or lower surface of the filter membrane and the receiving liquid throughout the entire experimental process; 10. The upper pipeline of the diffusion pool is used to eliminate bubbles; 11. Automatic sampling design, adding and absorbing media from the bottom of the diffusion pool, can achieve full flux sampling and partial sampling; 12. At the same time, conduct Penetration test on 12 samples. The upper and lower groups are 6+6 (reference+self-developed), and different temperatures and mixing speeds can be set. 13. Excellent flow path design, automatic lubrication of the pipeline before sampling, and automatic emptying of the pipeline after sampling to avoid cross contamination of the sample; 14. 12 pools are independent media channels that can simultaneously conduct 12 sets of release media inspections; 15. High precision imported injection pump, which can achieve fast and accurate sampling with a sampling error of ≤ ± 1%; 16. The sampler is automatically compatible with large test tubes (15ml) and liquid phase vials for sampling, with 36 sampling points; 17. The sampling system can perform online secondary filtration and can be equipped with an automatic membrane changer. Technical parameters: Instrument type: offline type Dissolution cup: 12 Temperature range: 20-60 ℃ Temperature accuracy: ± 0.1 ℃ Speed range: 100-1000rpm Water bath temperature control range: room temperature~45 ℃ Water bath temperature resolution: 0.1 ℃ Sampling volume: 1.5-12ml Sampling points: 36
Introduction: The TD-12AT automatic transdermal diffusion system consists of a diffusion host and a sample collector. The TD-12 transdermal diffusion host consists of two sets of 6+1 diffusion cells, with 6 diffusion cells used for diffusion experiments and the 7th diffusion cell used to monitor the temperature of the receiving solution. It meets the requirements of the US Pharmacopoeia and is a reliable and reproducible method for semi solid dosage form release determination. Mainly used for drug transdermal release tests of ointments, ointments, coatings, films, aerosols, and other formulations, to study the efficiency of drug penetration through the skin through a model of skin absorption.
