DS-BIOAT automatic reciprocating cylinder digestion system Introduction: The DS-BIOAT automatic reciprocating cylinder dissolution system consists of a reciprocating cylinder dissolution device and an automatic sampling workstation. Meet the relevant requirements of USP, Chinese Pharmacopoeia and European Pharmacopoeia. The device adopts a transparent hollow cylinder equipped with screens at both ends. The sample to be tested is placed in the cylinder and the screens at both ends are tightened before being placed in a dissolution cup containing dissolution medium and gently reciprocating up and down. The dissolution medium flows through a reciprocating cylinder through a sieve, providing shear force at the liquid-solid interface during the dissolution process of the drug. Suitable for the dissolution study of new drug formulations such as sustained-release, targeted release, and enteric coated delayed release formulations. Features: 1. Glass dissolution cup 300ml, 7-position, 6-row, in compliance with pharmacopoeia requirements; 2. The connecting rod reciprocating structure ensures that the reciprocating stroke is fixed and unchanged; 3. Better leakage conditions for better dissolution of low solubility drugs; 4. The standard design meets the requirement of fully automatic switching between multiple media, better simulating changes in human pH environment; 5. Less media required, easy to change pH, and good correlation with bioavailability data; 6. Online filtration function: two-stage filtration, columnar filtration, and 0.45um membrane circulation filtration. The 0.45um membrane is installed in the circulation pipeline to fully solve the problem of sample adsorption. During the experiment, no air is allowed to pass through the membrane, ensuring stable system pressure. 7. Software system a. 8.4 inch touch screen control, Huarong diffusion workstation, human-machine interaction, easy to operate; b. Can configure 1000 accounts and 1000 experimental methods; c. Paperless office report management, network printer can be connected, data can be stored locally, and backed up to USB flash disk or enterprise server; d. Data audit tracking function, three-level permission management, in compliance with FDA 21 CFR Part 11 requirements. Technical parameters: Instrument type: offline type Dissolution cup: 7 positions, 6 rows Temperature range: 20-60 ℃ Temperature accuracy: ± 0.1 ℃ Water bath temperature control range: room temperature~45 ℃ Water bath temperature resolution: 0.1 ℃ Water bath volume: 30L
Introduction: The DS-BIOAT automatic reciprocating cylinder dissolution system consists of a reciprocating cylinder dissolution device and an automatic sampling workstation. Meet the relevant requirements of USP, Chinese Pharmacopoeia and European Pharmacopoeia. The device adopts a transparent hollow cylinder equipped with screens at both ends. The sample to be tested is placed in the cylinder and the screens at both ends are tightened before being placed in a dissolution cup containing dissolution medium and gently reciprocating up and down. The dissolution medium flows through a reciprocating cylinder through a sieve, providing shear force at the liquid-solid interface during the dissolution process of the drug. Suitable for the dissolution study of new drug formulations such as sustained-release, targeted release, and enteric coated delayed release formulations.
